Exploring the Pharmacological Effects of Chinese Prickly Ash

Chinese Prickly Ash, scientifically known as Zanthoxylum bungeanum Maxim, is a plant native to China that has been utilized for both culinary and medicinal purposes for centuries. While its culinary use adds a distinctive flavor to dishes, its pharmacological effects have garnered attention in traditional Chinese medicine (TCM) and modern scientific research alike. This article aims to explore the pharmacological effects of Chinese Prickly Ash, shedding light on its potential health benefits and applications.

Antioxidant Properties

One of the key pharmacological effects of Chinese Prickly Ash is its potent antioxidant activity. The plant contains various bioactive compounds, including alkaloids, flavonoids, and phenolic compounds, which exhibit strong antioxidant properties. These compounds help neutralize harmful free radicals in the body, reducing oxidative stress and protecting cells from damage. Research suggests that the antioxidant activity of Chinese Prickly Ash may contribute to its anti-inflammatory, neuroprotective, and cardioprotective effects.

Anti-inflammatory Effects

In traditional Chinese medicine, Chinese Prickly Ash has long been used to alleviate pain and inflammation. Scientific studies have provided evidence supporting its anti-inflammatory properties. Compounds found in Chinese Prickly Ash have been shown to inhibit the production of inflammatory mediators and suppress inflammatory pathways in the body. As a result, it may offer relief from conditions such as arthritis, gastritis, and dermatitis.

Gastrointestinal Benefits

Chinese Prickly Ash is also known for its gastrointestinal benefits. It has been used to improve digestion, alleviate stomach discomfort, and relieve symptoms of gastrointestinal disorders. Research indicates that the plant may help stimulate gastric secretion, enhance intestinal motility, and protect the gastric mucosa against damage. These effects make it a valuable herb for promoting digestive health and treating digestive ailments.

◢ On experimental gastric ulcer: pepper water extract 5 and 10g/kg significantly anti-mouse flooding stress ulcer formation effect, and the ether extract only suppress tendencies. There pepper water extract 10g/kg mice indomethacin significantly inhibited ethanol-induced ulceration Singa, but inhibition rate (22%) is not high. 3.0ml/kg pepper ether extract significantly inhibited the formation of hydrochloric acid and ulcers in rats (P <0.01). 5g/kg pepper water extract can inhibit the formation of ulcers in the pylorus ligated rats.

◢  Impact of acute liver injury induced by carbon tetrachloride in rat serum GPT and GOT pepper water extract 5.0g/kg against carbon tetrachloride can increase the role of GPT (P <0.05 =, and a dose-dependent manner, But elevated GOT no antagonism.

◢  Impact on drug-induced diarrhea in mice: pepper ether extract 3.O and 6.0ml/kg mice against castor oil can be caused by diarrhea, the role appears not only fast, but also durable. Wherein the occurrence of diarrhea 3.0ml/kg group also delayed two hours (1.2 hours for the occurrence of the control group was 5/12 and 11/12, Japanese pepper extract 3.0ml/kg ether group was 0/12 and 5/12, P values were <0.05). Pepper 5 or 10g/kg water extract of senna-induced diarrhea in mice confrontation role, the role of produce slow but persistent (P <0.05). 4 ink on mouse gastrointestinal propulsive movement mice fed 10g/kg pepper water extract can inhibit gastrointestinal propulsive motility, P <0.05.

On Experimental Thrombosis and Coagulation System

The use of electrical stimulation-induced arterial wall in vivo experimental thrombosis and simultaneous determination of its effects on blood coagulation. The experimental results showed that: water extract of pepper and pepper under 10-20g/kg ether extract 0.3ml/kg dose significantly inhibited thrombosis in rats (P <0.01 and P <0.001 =, can significantly prolong experimental thrombosis time, suggesting a role in the prevention of thrombosis. has some anticoagulant effect of aqueous extract of pepper and ether extract 0.15-0.3ml/kg 10g/kg dose, aqueous extract of the anticoagulant effect is stronger than the ether extract. pepper antithrombotic, anticoagulant effect may be related to platelet function anticoagulant component related to vascular endothelial cells, because the pepper water extract of ADP and collagen-induced platelet aggregation significantly inhibited, the inhibition rate was 50.4%, 88.3%, respectively. This product contains a certain confrontation bergapten anticoagulant effect of heparin and hemostasis.

Analgesic Effect

Water extract 5-10g/kg pepper and ether extract 3.0-6.0ml/kg of acetic acid-induced writhing in mice significantly inhibited the reaction, aqueous extract of P <0.05, ether extract matter 3.0ml/kg (P <0.05), ether extract 6.0ml/kg (P <0.01), which is more effective than the ether extract water extract strong dose-dependent manner.

Inhibitory Effect

This product dermatophytes 11 kinds of volatile oil and four deep fungal inhibition and have a certain role in the killing, one of the most sensitive to wool-like small spores and Trichophyton rubrum, MIC below 0.1HL/ml , MFC is 0.1HL/ml. Experiments confirmed Azone and dimethyl sulfoxide in the volatile oil can promote fungal cells into accelerated cell death.

Deworming Effect

Pepper volatile oil contained in the insulation can Ascaris Ringer solution in severe poisoning.

Cardioprotective Effects

Studies suggest that Chinese Prickly Ash may exert cardioprotective effects, primarily due to its antioxidant and anti-inflammatory properties. It may help lower blood pressure, improve blood lipid profiles, and reduce the risk of cardiovascular diseases. Additionally, certain compounds found in Chinese Prickly Ash have been found to possess vasodilatory effects, which can enhance blood flow and circulation.

Neuroprotective Effects

Chinese Prickly Ash has shown promise in promoting brain health and protecting against neurodegenerative diseases. Research indicates that its bioactive compounds may help enhance cognitive function, protect neurons from damage, and reduce the risk of conditions such as Alzheimer's disease and Parkinson's disease. Furthermore, its anti-inflammatory and antioxidant properties contribute to its neuroprotective effects.

Other Effects

This product contains alkali skimmianine have ephedrine-like effects, but the strength is weak, can increase blood pressure in anesthetized cats, enhance haw contraction, strengthening the role of adrenaline on blood pressure and uterine strengthen cat or rabbit The reign of uterine contractions, inhibiting intestinal contraction and dilation of coronary blood vessels, improving striated muscle tension, strengthen the spinal reflex excitability. There is a strong antibacterial effect.ugh; caries toothache; Yin Yang vaginal discharge; eczema itchy skin.

Conclusion

Chinese Prickly Ash exhibits a wide range of pharmacological effects, making it a valuable herb in traditional Chinese medicine and a subject of interest in modern scientific research. From its antioxidant and anti-inflammatory properties to its benefits for gastrointestinal health, cardiovascular health, and neuroprotection, this plant offers promising therapeutic potential. Further studies are needed to fully elucidate its mechanisms of action and explore its applications in clinical settings. Nonetheless, Chinese Prickly Ash stands as a testament to the rich pharmacological heritage of traditional Chinese medicine.

Contact Manna Foods

Weifang Manna Foods Co.,Ltd is a manufacturer and exporter specializing in processing and selling various Sichuan peppercorns. The company was registered with the industrial and commercial department in 2006. Its main products include green pepper and red pepper. It has been successfully sold to the United States, Japan, Canada, Europe, the Middle East, Taiwan and other countries and regions. If you have any need please feel free to contact us.